From the perspective of the Supreme Leader (Mudzaleh), the Islamization of the humanities is of particular importance and necessity in achieving major goals such as raising the lofty edifice of the modern Islamic civilization and the success of the Islamic system. The present study examines what model should be used for the Islamization of the humanities from his perspective, and how can seminaries, as centers for exploring religious knowledge and producing Islamic sciences, play a role in this process? To answer these questions, an attempt has been made to extract the views of the Supreme Leader based on the method of content analysis and a comprehensive model for the Islamization of the humanities in civilization, focusing on the role of seminaries. This model emphasizes components such as identifying the goals of the Islamization of the humanities, identifying strengths, weaknesses, opportunities, and threats related to the Islamization of the humanities, and the strategies and policies necessary for the Islamization of the humanities. According to the findings of this study, producing divine knowledge with the aim of human happiness and providing the necessary sciences to create a new Islamic civilization are the major goals, and discovering the foundations of humanities based on Islamic thought and Islamic worldview, and infusing Islamic worldview in humanities are introduced as one of the intermediate goals of Islamizing humanities. Also, discourse-building, formulating the scientific and philosophical basis for the evolution of humanities, and discovering the foundations of humanities based on Islamic and divine worldviews and with a rigorous and ijtihadic method are among the important strategies for Islamizing humanities, focusing on the role of seminaries, as some of the most important strategies in this field.