Ethics and political ethics are essential elements in the formation of civilizations, in which wisdom has a serious presence in their foundation, on this basis, the main purpose of this article is to examine the place of wisdom and its effect on political ethics with a civilizational approach and referring to the thought of Ayatollah Khamenei (goal) The main question of this article is to examine the civilizational approach to wisdom in political ethics with an emphasis on Ayatollah Khamenei's point of view. It is necessary to achieve the truth of moral wisdom and moral ethics, and in the new reading of moral texts, in accordance with the conditions of effort and thinking for the new Islamic civilization, it can lead our society to new achievements. (statement of the problem) while paying attention to the wisdom of Islamic civilization and its value in religious texts and the correlation between wisdom and civilization in the thought of Ayatollah Khamenei, in the findings of the research and hypothesis, it is emphasized that wisdom is beside itself. Prudence, moderation, justice, knowledge, and wisdom are brought to the fore, things that regulate power relations and create a platform for the movement of society and the Islamic state towards civilization, when wisdom is present in the political ethics and moral relations of the Islamic state. found, freedom and civilized wisdom, political justice and free dialogues and civilization-creating interactions are widespread, which can provide the basis for achieving a new Islamic civilization. (Findings) A practical and descriptive-analytical method has been carried out, which is an innovative effort in its own way. (Methodology).